Results
| PMID | 26334889 |
| Gene Name | FCRL3 |
| Condition | Endometriosis |
| Association |
Associated |
| Mutation | FCRL3 (rs7528684, rs11264799, rs945635, rs3761959) |
| Population size | 437 |
| Population details | 437 (217 patients suffering from endometriosis-related infertility, 220 healthy controls) |
| Sex | Female |
| Infertility type | Female infertility |
| Other associated phenotypes |
Endometriosis-Related Infertility |
|
Medicine (Baltimore). 2015 Sep;94(35):e1168. doi: 10.1097/MD.0000000000001168. Zhang, Haiyan| Zhang, Zhen| Li, Guang| Wang, Surong| Zhang, Shiqian| Xie, Beibei From the Department of Gynecology, Affiliated Qilu Hospital of Shandong University, Jinan, China (HZ) and Gynecology Ward-1 (HZ, ZZ, BX); Department of Gastrointestinal Surgery (GL), and Gynecology Ward-3 (SW), Linyi City People's Hospital, Shandong Pr The Fc receptor-like 3 (FCRL3) gene was reported to be linked to a variety of autoimmune diseases, including endometriosis-related infertility. However, this linkage has not been studied in Chinese population and there has been no meta-analysis on the interrelationship of FCRL3 gene and endometriosis-related infertility. The aim of the study was to investigate the association between FCRL3 genetic polymorphisms and the risk of endometriosis-related infertility in Han Chinese, and a further meta-analysis was conducted to confirm our results.Four single nucleotide polymorphisms (SNPs) (rs7528684 [FCRL3_3], rs11264799 [FCRL3_4], rs945635 [FCRL3_5], and rs3761959 [FCRL3_6]) on FCRL3 gene were genotyped in a case-control cohort composed of 217 patients suffering from endometriosis-related infertility and 220 healthy controls using cleaved amplification polymorphism sequence-tagged sites (polymerase chain reaction-restriction fragment length polymorphism, PCR-RFLP). Odds ratio (OR) and its 95% confidence interval (CI) was used to evaluate the association quantitatively. Furthermore, a meta-analysis of previous studies including the present study was implemented through Stata 11.0 (Stata Corporation, College Station, TX).We found an approximately 1.4-fold significantly increased frequency of the FCRL3_3 variant in women with endometriosis-related infertility over the controls (OR = 1.41 [95% CI = 1.08-1.84], P = 0.013). However, no significant difference was found between women with endometriosis-related infertility and controls for FCRL3_4, FCRL3_5, and FCRL3_6. Regardless of the symptoms and the revised classification of the American Society of Reproductive Medicine (rASRM) stage of endometriosis, there was a significant association between FCRL3_3 variant and an increased risk of endometriosis-related infertility. Meta-analysis of previous studies combined with the present study further confirmed the association between FCRL3_3 and the risk of endometriosis-related infertility.In summary, the present study suggested that FCRL3_3 variant was associated with an increased risk of endometriosis-related infertility, regardless of symptoms, and rASRM stage of the patients. Meta-analysis of previous studies combined with the present study further confirmed our results. Further large-scale studies in the future are warranted to explore the association between FCRL3 genetic polymorphisms and endometriosis-related infertility, as well as other human diseases, in Asian and other ethnicities. Mesh Terms: Adult| Asian Continental Ancestry Group/*genetics| Case-Control Studies| Endometriosis/complications/*genetics| Female| Genetic Predisposition to Disease/genetics| Genotype| Humans| Infertility, Female/etiology/*genetics| Polymorphism, Single Nuc |
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